Directory

Balaji Narasimhan

  • Vlasta Klima Balloun Professor

Main Office

2035 Sweeney Hall
Ames, IA 50011-2150
Phone: 515-294-8019
Fax: 515-294-9273




Education

Ph.D. Chemical Engineering, Purdue University, 1996
B.S. Chemical Engineering, Indian Institute of Technology, Bombay, 1992 

Interest Areas

BALAJI NARASIMHAN'S RESEARCH PAGE

Our research is focused on the molecular design of nanoscale polymer systems and biomaterials to precisely control molecular architecture and functionality in these systems. The overall goal is to answer critical questions related to organization and dynamics occurring on length scales ranging from the nanometer to the micron-scale at surfaces of and interfaces between nanoparticles, inorganic materials (e.g., Si surfaces), cells, and biomolecules (e.g., drugs, proteins). The tools that we utilize include novel synthesis methodologies, precise functionalization of nanoparticles, and state-of-the-art surface/interfacial characterization.

Our current research thrusts are in the areas of functionalized nanoparticles for targeted vaccine and drug delivery, rational protein stabilization strategies using nanostructured biodegradable block copolymers, multifunctional nanoparticles for biosensing and enzymatic catalysis, and the development of combinatorial and high throughput technology for synthesis and testing of biomaterials. Our research is currently funded by NSF, NIH, DOD, HRSA, and the Roy J. Carver Foundation.

Brief Biography

Honors and Awards
Fellow, American Association for the Advancement of Science, 2011
Plenary Speaker for Area 15, Annual AIChE Meeting, Minneapolis, MN, 2011
IITSINE Alumni Service Award, 2011
Vlasta Klima Balloun Professor of Engineering, 2010
Iowa State University Award for Mid-Career Achievement in Research, 2008
Fellow, American Institute for Medical and Biological Engineering, 2008
Named by MIT’s Technology Review Magazine as one of the World’s Top 100 Young Innovators with the TR100 Award, 2003
ISU Foundation Early Excellence in Research Award, 2003
3M Non-Tenured Faculty Award, 2003
ISU Engineering Student Council Leadership Award, 2002
Whitaker Foundation Biomedical Engineering Research Award, 2000 
Best Doctoral Dissertation in Mathematics, Physical Sciences, and Engineering, Purdue University, 1996

Selected Publications

  • L. M. Huntimer, J. H. Wilson-Welder, K. A. Ross, B. Carrillo-Conde, L. Pruisner, C. Wang, B. Narasimhan, M. J. Wannemuehler, and A. E. Ramer-Tait, "Single immunization of a suboptimal dose of antigen encapsulated into polyanhydride microparticles promotes high titer and avid antibody responses," J Biomed Mater Res B, 101B, 91-98 (2013)
  • L. M. Huntimer, A. E. Ramer-Tait, L. K. Petersen, K. A. Ross, K. A. Walz, C. Wang, J. M. Hostetter, B. Narasimhan, and M. J. Wannemuehler, "Evaluation of biocompatibility and administration site reactogenicity of polyanhydride particle-based platform for vaccine delivery," accepted for publication in Adv Healthcare Mater (2012)
  • V. B. Joshi, S. M. Geary, B. R. Carrillo-Conde, B. Narasimhan, and A. K. Salem, "Characterizing the anti-tumor response in mice treated with antigen-loaded polyanhydride microparticles," accepted for publication in Acta Biomater (2012)
  • F. Jia, B. Narasimhan, and S. K. Mallapragada, "Biomimetic multi-enzyme complexes based on nanoscale platforms," accepted for publication in AIChE J (2012)
  • F. Jia, Y. Zhang, B. Narasimhan, and S. K. Mallapragada, "Block copolymer-quantum dot micelles for multi-enzyme co-localization," Langmuir 28, 17389-17395 (2012)
  • B. Carrillo-Conde, A. E. Ramer-Tait, M. J. Wannemuehler, and B. Narasimhan, "Chemistry-dependent adsorption of serum proteins onto polyanhydride microparticles differentially influences dendritic cell uptake and activation," Acta Biomater 8, 3618-3628 (2012)
  • B. Carrillo-Conde, R. Roychoudhury, A. V. Chavez-Santoscoy, N. L. B. Pohl, and B. Narasimhan, "High throughput synthesis of carbohydrates and functionalization of polyanhydride nanoparticles," J Vis Exp (65), e3967, DOI:10.3791/3967 (2012)
  • L. K. Petersen, A. V. Chavez-Santoscoy, and B. Narasimhan, "Combinatorial synthesis of and high-throughput protein release from polymer film and nanoparticle libraries," J Vis Exp (67), e3882, DOI:10.3791/3882 (2012)
  • A. V. Chavez-Santoscoy, L. M. Huntimer, A. E. Ramer-Tait, M. J. Wannemuehler, and B. Narasimhan, "Harvesting alveolar macrophages and evaluating cellular activation induced by polyanhydride nanoparticles," J Vis Exp (64), e3883, DOI:10.3791/3883 (2012)
  • Y. Phanse, A. E. Ramer-Tait, S. L. Friend, B. Carrillo-Conde, P. Lueth, C. J. Oster, G. J. Phillips, B. Narasimhan, M. J. Wannemuehler, and M. H. Bellaire, "Analyzing cellular internalization of nanoparticles and bacteria by multi-spectral imaging flow cytometry," J Vis Exp (64), e3884, DOI:10.3791/3884 (2012)
  • A. Chavez-Santoscoy, R. Roychoudhary, A. E. Ramer-Tait, N. L. Pohl, M. J. Wannemuehler, and B. Narasimhan, "Tailoring the immune response by targeting C-type lectin receptors on alveolar macrophages using pathogen-like amphiphilic polyanhydride nanoparticles," Biomaterials, 33, 4762-4772 (2012)
  • L. K. Petersen, Y. Phanse, A. E. Ramer-Tait, M. J. Wannemuehler, and B. Narasimhan, "Amphiphilic polyanhydride nanoparticles stabilize Bacillus anthracis protective antigen," Mol Pharmaceutics 9, 874-882 (2012)