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ERI Funding Opportunities

Welcome to the ERI Funding Opportunities Site

College of Engineering campus
Research drives excellence in the College of Engineering by serving as a magnet to attract and retain outstanding faculty and students. Funding opportunities relevant to the College of Engineering will be posted here. If you are interested in pursuing any of these opportunities please contact ERI at eri-pre@iastate.edu for assistance or additional information. New opportunities are posted weekly. To have the new opportunities delivered directly to your inbox please subscribe using your ISU email address. One email per week.

Advancing Bioinformatics, Translational Bioinformatics and Computational Biology Research (R01 Clinical Trial Optional)

NIH

Solicitation: FOR-LM-25-001

https://www.grants.gov/search-results-detail/359003

Posted Date: July 22, 2025

Estimated Application Release Date: October 06, 2025
Estimated Application Due Date: February 04, 2026

Notice of intent only

The National Library of Medicine (NLM) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research that drives groundbreaking innovation and advanced development in the fields of bioinformatics, translational bioinformatics, and computational biology. The primary goal of this initiative is to support the creation and implementation of cutting-edge methods, tools, and approaches that can transform the landscape of biomedical data science.

This NOFO aims to address the growing need to leverage transformative technologies—such as artificial intelligence (AI), machine learning, and large-scale computational platforms—to extract actionable knowledge from vast, diverse, and complex biological datasets. By enabling more effective interpretation and integration of multi-dimensional biological and biomedical data, this research will ultimately contribute to improving individual and population health outcomes.

Applications that promote interdisciplinary collaboration and focus on scalable, autonomous innovations will be encouraged. Projects may span a wide range of topics, including but not limited to omics-based bioinformatics at the molecular level, as well as computational biology studies at the cellular, tissue, organismal, and population levels. Emphasis will be placed on research that exemplifies scientific rigor, technological innovation, and the potential for significant impact across biomedical and clinical domains.

Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the R01 activity code. Investigators with expertise and insights into advancing the bioinformatics and computational biology fields are encouraged to begin to consider applying for this new NOFO.

Research Grants in Clinical Informatics (R01 Clinical Trial Optional)

NIH

Solicitation: FOR-LM-25-002

https://www.grants.gov/search-results-detail/359004

Posted Date: July 22, 2025

Estimated Application Release Date: October 06, 2025
Estimated Application Due Date: February 04, 2026

Notice of intent only

The National Library of Medicine (NLM) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for innovative research in clinical informatics. The overarching goal of this forthcoming program is to catalyze the development and advancement of novel informatics methodologies that empower clinicians, patients, and the broader public to better understand, manage, and improve health and health care delivery.

This NOFO will support research focused on the design, implementation, and evaluation of clinical informatics tools and methods that enable data-driven discovery, promote evidence-based decision-making, and support personalized and precision health care. Emphasis will be placed on domain-independent, scalable, and reusable/reproducible approaches for the discovery, analysis, organization, and management of health-related digital objects—including electronic health records (EHRs), clinical notes, imaging data, and patient-generated data.

The aim is to transform raw and heterogeneous health data into actionable knowledge, to develop innovative tools, and to implement practical applications that can be generalized across multiple clinical settings and populations. Projects should demonstrate the potential to accelerate scientific insights, improve clinical workflows, and ultimately lead to improved health outcomes.

Research outputs are expected to be transformative, broadly applicable, and sustainable. The program will encourage the formation of interdisciplinary collaborations, particularly those that combine clinical informatics expertise with advances in data science, machine learning, human-centered computing, and other relevant domains.

Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the R01 activity code. Investigators with expertise and insights into this area of clinical informatics are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in data science will be encouraged and these investigators should also begin considering applying for this application.

Request for Information: Government Team for the Heterogeneous Architectures for Quantum (HARQ)

DARPA

Solicitation: DARPA-SN-25-99

https://sam.gov/workspace/contract/opp/60a268d1ccbc498a9f04e8751c4dbd29/view

Posted date: July 22, 2025

Proposal Due date: August 15, 2025

DARPA Microsystems Technology Office (MTO) seeks information on capabilities, infrastructure, expertise, resources available to pursue the goals of the Heterogeneous Architectures for Quantum (HARQ) program. The principal objective of HARQ is to establish a new heterogeneous quantum computing (QC) paradigm that eliminates the constraints of homogeneous, single-qubit platforms. HARQ is structured to assess the plausibility of heterogeneous architectures and test whether they are inherently more scalable than homogeneous architectures through a concerted, multi-thrust effort. Special Notice DARPA-SN-25-98 describes the two performer technical areas (TAs) planned for the program: TA1 focuses on QC circuit optimization using heterogeneous qubit resources, and TA2 focuses on interconnect hardware between heterogeneous qubit platforms. This RFI seeks responses from interested parties to participate in the third thrust of the program—a heterogeneous QC architecture study by a Government Team comprising one or more organizations alongside DARPA. This RFI also seeks responses from interested parties to perform multiple efforts in independent verification and validation (IV&V), test and evaluation (T&E), and program oversight of performer efforts. Based on the information provided in the responses, DARPA plans to engage in follow-on discussions with responders to develop projects supporting the enclosed tasks. Note that DARPA may request multi-party discussions to develop collaboration efforts to fully cover the requested tasking. Responses are welcome from all capable sources including, but not limited to, U.S. Government labs, federally funded research and development centers (FFRDCs), university-affiliated research centers (UARCs), not-for-profit research institutions, and other government-affiliated institutions. To avoid conflicts of interest, DARPA will not allow UARCs, FFRDCs, government laboratories, not-for-profit research institutions, and other government-affiliated institutions to propose as performers under the forthcoming HARQ solicitation.

Future Program Announcement & Proposers Day: Heterogeneous Architectures for Quantum (HARQ)

DARPA

Soliciation: DARPA-SN-25-98

https://sam.gov/workspace/contract/opp/e5aea4084d00433f9a93de44c0be8b48/view

Posted date: July 23, 2025

Feedback should be emailed to HARQ@darpa.mil no later than July 30, 2025, at 5:00 p.m. ET

DARPA will post the final PS. DARPA will host a virtual Proposers Day in support of DARPA Program Solicitation (PS) DARPA-PS-25-31 for HARQ on August 8, 2025, via webcast from 11:00 a.m. to 4:00 p.m. ET.

DARPA anticipates soliciting innovative proposals towards the realization of heterogeneous quantum computing architectures. Proposed research would investigate innovative approaches that enable revolutionary advances in theory, devices, and system concepts for quantum interconnects, quantum circuit compilers, distributed algorithms, resource estimation, quantum memory/repeater devices, quantum frequency converters, microwave-to-optical transducers, and other elements at the interface of the quantum computing hardware/software stack. Specifically excluded is research that primarily results in evolutionary improvements to the existing state of practice. See Future Program Details section below. DARPA welcomes feedback on the HARQ program goals, metrics, and scope outlined in Future Program Details section below. Feedback should be emailed to HARQ@darpa.mil no later than July 30, 2025, at 5:00 p.m. ET, after which time DARPA will post the final PS. DARPA will host a virtual Proposers Day in support of DARPA Program Solicitation (PS) DARPA-PS-25-31 for HARQ on August 8, 2025, via webcast from 11:00 a.m. to 4:00 p.m. ET. DARPA anticipates releasing DARPA-PS-25-31 prior to Proposers Day. See Proposers Day Details section below for additional registration and meeting details.

National Science Foundation Translation to Practice (NSF TTP)

NSF

Solicitation: 25-540

https://www.nsf.gov/funding/opportunities/nsf-ttp-national-science-foundation-translation-practice/nsf25-540/solicitation

Posted Date: July 09, 2025

Proposal Due Dates:  (due by 5 p.m. submitting organization’s local time):

September 16, 2025, and the Third Tuesday in September, Annually Thereafter.

January 20, 2026, and the Third Tuesday in January, Annually Thereafter.

May 19, 2026, and the Third Tuesday in May, Annually Thereafter.

The translation of research to practice ensures that the insights and innovations developed through scientific study and experimentation have tangible, positive impacts for the Nation. These impacts include improving the quality of life, promoting economic and job growth, ensuring national security, and maintaining global competitiveness. Indeed, scientific and engineering breakthroughs have the potential to address critical societal challenges in industries such as aerospace, agriculture, communications, education, energy, healthcare, national security, and transportation – but the translation of discoveries and innovations from the laboratory to society often takes many forms including non-linear pathways.

The NSF TTP program was developed with several goals in mind:

  • To identify and support use-inspired research and translational activities enabling a continuum from foundational research to practice;
  • To develop partnerships and collaborations between institutions of higher education and other entities (e.g., industry, state/local/national government agencies, philanthropies, open-source ecosystems, for-benefit, for-profit and non-profit organizations, international organizations, etc.);
  • To promote and advance the education and training of students and postdoctoral researchers, encouraging the participation of all Americans in STEM including innovation and entrepreneurship; and
  • To identify future customer needs and opportunities and bring these to the forefront in the conduct of use-inspired research and translational activities.

Research and Development Innovations Broad Agency Announcement

DOD

Solicitation: HDTRA122S0003

https://sam.gov/workspace/contract/opp/d5bcd60592c84adf908c5c1ca747bc4e/view

Posted date: July 22, 2025

BAA close date: February 28, 2027

DTRA enables the Department of Defense (DoD), U.S. Government, and international partners to counter and deter weapons of mass destruction (WMD) and emerging threats. With this BAA, DTRA is soliciting innovative proposals for technologies in the technology readiness level (TRL) 1-7 range that will lead to new or improved technical solutions for countering and deterring WMD and other emerging threats. Guidance in the 2022 DTRA Strategy for Research, Development, Test, and Evaluation describes emerging threats as “new or developing WMD materials or intent, including the hazard itself and/or its science, technology, methodology, development, production, proliferation, and means of delivery.” For WMD, the development of materials or methodologies with the potential to create new or increase the impact of existing forms of traditional WMD can be considered “emerging threats.” A novel pathogen, a new means to deliver chemical or biological weapons, or the use of traditional WMD material in new or previously unknown ways, for instance, can all be seen in this light. In executing the 2022 DTRA Strategy for Research, Development, Test, and Evaluation, this BAA seeks optimum approaches to meet DTRA research, development, test, and evaluation (RDT&E) priorities. The Government encourages white papers and proposals that span a wide spectrum of research to expand scientific knowledge in response to specific topics and to the more general thrust areas. The Government reserves the right to award any combination of approaches which offer the best overall value to the Government and to oversee any and all processes and approaches once ongoing.

Innovative Solutions for Improving Water Quality and Strengthening Local Economies in the Gulf of America Watershed

Environmental Protection Agency

Solicitation: EPA-R4-GAD-2025-WQ

https://www.grants.gov/search-results-detail/358752

Posted date: July 21, 2025

Proposal Due date: September 19, 2025

The Gulf of America Division, located in U.S. Environmental Protection Agency (“EPA”) Region 4, is part of the EPA Great Water Body program that collaborates to protect, maintain, and restore the health and productivity of the Gulf of America consistent with the economic well-being of the region. EPA’s actions are designed to support improved water quality; to enhance, restore and/or protect natural habitats; and to improve the region’s ability to withstand storm events. This notice announces the availability of funds and solicits applications to improve water quality and/or Gulf habitat through nutrient reduction and/or mitigation of harmful algal blooms (“HABs”), including Sargassum Inundation Events, via demonstration projects that are enhanced by innovative technology. Applications must align with the Administration’s “Powering the Great American Comeback” initiative and align with EPA statutory authorities. Activities must take place in the Gulf of America watershed within the contiguous United States.

Clinical Data Ecosystem for Genomics (CDEG)

NIH

Solicitation: FOR-HG-26-005

https://www.grants.gov/search-results-detail/359208

Posted Date: July 17, 2025

Estimated Application Release Date: December 01, 2025
Estimated Application Due Date: March 02, 2026

Notice of intent only

The National Human Genome Research Institute (NHGRI) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research reduce barriers to a Clinical Data Ecosystem for Genomics (CDEG) by establishing a network to identify, share, and improve approaches for clinical integration and sharing of genome sequencing data and their interpretation as structured data among labs, health care providers, and patients. Specifically, the Network will: 1) establish a pilot ecosystem that demonstrates best practices for the sharing of genomic structured data (GSD) across different health care settings, including primary care; 2) create standardized application programming interfaces (APIs) to support access to such data; 3) develop open-source clinical software applications and databases that utilize these APIs; 4) demonstrate the ability of the pilot ecosystem to overcome barriers to accessing patient genomic data as patients travel across healthcare systems; and 5) refine and develop these practices into implementation resources for broader sharing and adoption. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U01 activity code. Investigators with expertise and insights into this area of genomic medicine and implementation science are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in computational genomics and data science, electronic health records (EHR), genomic data standards, cloud and database development, health information exchange, and implementing genomics in clinical care will be encouraged and these investigators should also begin considering applying for this application. 

Command Wide Broad Agency Announcement for Naval Facilities Engineering and Expeditionary Warfare Center (NAVFAC EXWC) Research, Development, Testing, and Evaluation

DOD 

Solicitation: N3943025S4500

https://sam.gov/workspace/contract/opp/e3d24e28b52c4bd0a13e42b95d457ee0/view

Posted date: July 16, 2025

Proposal Due date: June 12, 2026

This announcement constitutes a Broad Agency Announcement (BAA) for the Naval Facilities Engineering and Expeditionary Warfare Center (NAVFAC EXWC) under FAR 6.102(d)(2) and FAR 35.016. This announcement is open for one year and will be advertised annually. NAVFAC EXWC provides research, development, testing, and evaluation (RDT&E) to deliver specialized facility, ocean system, and expeditionary solutions to the warfighter. To be eligible for consideration and possible contract award, the technology or methodology shall be in either applied research (Category 6.2), advanced technology development (Category 6.3), or advanced component development and prototypes (Category 6.4) (https://www.dau.edu/glossary/research-development-test-and-evaluation-budget-activities).

MDA-STEM-BEST-ROBOTICS-GRANT-2025-2026

DOD

https://www.grants.gov/search-results-detail/360035

Posted date: July 16, 2025

Proposal Due date: August 20, 2025

The Missile Defense Agency (MDA) Science, Technology, Engineering, and Mathematics (STEM) Outreach Program’s goal is to: Increase STEM awareness and proficiency among K-12 and college students to enhance the number of U.S. scientists and engineers capable of solving future missile defense challenges in the government, industry, and academia.

MDA STEM’s participation in this initiative aligns with the MDA efforts to develop and foster an engaged STEM talent pool. By making these proactive investments, MDA STEM strengthens and broadens the STEM competent talent pool across the education continuum to support future workforce needs.

The MDA STEM Boosting Engineering, Science, and Technology (BEST) Robotics Grants provide a means for official Local Competition Hubs, to obtain financial support for upgrading the robotics kits, in accordance with the BEST Inc. guidance for the 2025 or 2026 competition season.

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