ERI Funding Opportunities

DARPA

Solicitation: DARPA-SN-25-82

https://sam.gov/opp/73e4e374fac34f04a5e8f6aceeee9883/view

Posted Date: June 06, 2025

Registration Due Date: June 23, 2025 by 5:00 pm ET  Register HERE

Industry Day Date: June 30, 2025 at 9:00 am ET

PROGRAM OBJECTIVE AND DESCRIPTION:
The objective of the PROSE program is to demonstrate molecular readers that can accurately read a
broad range of amino acids and post translational modifications (i.e., letters) in sequence for unknown
protein samples. The program will seek hardware demonstrations of novel read element designs
integrated with microsystem architectures. The program is open to a wide range of translocation and
measurement approaches as well as microsystem designs. However, these approaches must overcome
the challenges associated with reading long protein sequences with high accuracy at high throughput.
Additionally, the readers must demonstrate scalability across the broad range of chemical complexity in
the protein letter space.

It is anticipated that PROSE will be a 36-month program with a 15-month Phase 1 and a 21-month Phase
2. It is anticipated that Phase 1 will focus on demonstrating novel read-element approaches to reading
the protein alphabet at high accuracy. It is anticipated that in Phase 1, performers will also develop
microsystem designs, amino acid calling algorithms, and models to predict throughput and accuracy of
designed microsystems. It is anticipated that Phase 1 will culminate with a technical demonstration of
read element capabilities, as well as a design review of microsystem performance with a simulation/projection of accuracy and throughput capability.
It is anticipated that Phase 2 will focus on realizing complex microsystems capable of high-accuracy, fulllength protein sequencing through novel fabrication and integration approaches. In Phase 2, it is also
anticipated that there will be a series of technical demonstrations showcasing improved read-element
performance across a broader chemical complexity space.

DARPA

Solicitation: DARPA-SN-25-79

https://sam.gov/opp/bc32a2465de44f18b39883094bfb448c/view

Posted Date: June 10, 2025

Registration Deadline: July 02, 2025 by 12:00 PM

Conference Date: July 07, 2025  in Arlington, VA.

The Proposers Day goals include:
1. Introducing the CoasterChase program vision and goals to the research community;
2. Explaining the mechanics of a DARPA program in general and the objectives and milestones of this program in particular;
3. Increasing efficiency in proposal preparation and evaluation;
4. Encouraging and promoting teaming arrangements among organizations that have the relevant expertise, research facilities, and capabilities for executing research and development responsive to the CoasterChase program goals.
The Proposers Day will include brief overview presentations by government personnel as well as an information session during which the DARPA Program Manager, BAA coordinator, and Contracting Officer will respond to questions from participants. The Proposers Day will also include 5-minute “lightning talks,” during which potential performers can highlight their technical capabilities to facilitate teaming relationships. CoasterChase will require strong teaming efforts to successfully innovate and integrate multidisciplinary critical technologies necessary to meet all of the metrics of the program.